The future of excessive sweat control
Humanity has been on a quest to control excessive sweating (also known as the medical condition of hyperhidrosis) since the earliest days of recorded history. From the first U.S. patent issued for a deodorant using ammonium chloride in 1867 to the first use of oral medications in the 1950s that disrupted neurotransmitter signals1, approaches to sweat control have evolved as technology has advanced. Today, people are still seeking the most modern approaches to excessive sweat control, including non-toxic, non-invasive, non-staining, and time-saving solutions.
Egyptians regularly used plants and food to create perfumes that mask or alter odors.
In 1867, the first U.S. patent for deodorant was issued to Henry D. Bird of Petersburgh, VA. The active ingredient was ammonium chloride. Another patent was issued to George T. Southgate of Forest Hills, PA, for a deodorant using yeast as an active ingredient.
The first trademarked deodorant was launched called Mum®. It used the antiseptic zinc oxide.
Developments during this time included roll-on and aerosol spray options, both of which dried quickly on the skin. The 1950s and 1960s were also when many physicians started using oral anticholinergic medications off-label to treat excessive sweating. These medications typically disrupt neurotransmitter signals to reduce sweating, but can cause systemic side effects such as dry mouth and constipation. Many of these oral treatments – including methantheline and glycopyrronium bromide – are used today in new formulations.
In the United States, botulinum toxin injections (onabotulinumtoxinA; Botox®) are approved for the treatment of severe primary axillary hyperhidrosis (excessive underarm sweating). While effective, the treatment is costly for patients and can cause discomfort at the injection sites.
MiraDry® was cleared in the United States for primary axillary hyperhidrosis (excessive underarm sweating). The treatment uses microwave energy to destroy the sweat glands.
Qbrexza® was approved in the United States as a topical anticholinergic for the treatment of primary axillary hyperhidrosis (excessive underarm sweating). The topical treatment, which requires a medical diagnosis and prescription, includes individually packaged wipes that are used at home once per day under the arms.
Candesant® Biomedical is developing a non-toxic, non-invasive, non-staining, quick and easy solution under investigation for the reduction of axillary hyperhidrosis (excessive underarm sweating). This “TAT” (targeted alkali thermolysis) patch is single-use and disposable. The TAT patch uses alkali metal that creates thermal energy when it interacts with underarm sweat, microtargeting sweat glands and temporarily inactivating them to reduce sweating. Clinical studies show that the TAT patch significantly reduces sweat. The TAT patch is applied by a healthcare professional for up to three minutes per underarm. The TAT patch is undergoing review by the U.S. FDA.
It is reported that nearly 15 million Americans are impacted by excessive sweating somewhere on their body, and approximately half of those people experience this sweating under the arms. 4, 5 Many believe these numbers are an underestimation, as people often suffer in silence through the physical, social, emotional, and financial effects of excessive sweating.6, 7 In fact, research shows that as many as 1 in 3 people are bothered by excessive underarm sweating. 8
Current excessive sweating treatments reduce sweat in a multitude of ways, but with varying degrees of efficacy. In a recent survey, healthcare providers stated that 63% of patients are not satisfied with prescription topical antiperspirants, 55% are not satisfied with topical wipes, and 45% are not satisfied with oral treatments. While cost is the main reason cited for why patients are not satisfied, nearly 1 in 5 say it is because the treatments don’t work well enough or not at all.9
Systemic Treatments (orals, injectables) – e.g., anticholinergics, alpha-adrenergic agonists, calcium channel blockers, botulinum toxin injections
Device-Based Treatments – e.g., microwave thermolysis, iontophoresis, lasers
Surgical Management – e.g., sympathectomy
Introducing Candesant’s Modern
Throughout history, technology has led to innovations in excessive sweat control – from aerosol deodorant sprays to microwave energy. However, some of these innovations have come with drawbacks including leaving clothes stained or involving injections or surgery. Now, a new technology is on the horizon that is non-toxic, non-invasive, and non-staining.
SweatTalks: Why excessive sweat speaks volumes before a word is spoken
It’s clear that new treatment options are needed to help control excessive sweat. In a recent consumer survey, dermatologists and plastic surgeons were the most commonly cited sources of information that influence aesthetic treatment decisions (53%). The same survey found that of aesthetically-minded consumers who are bothered by excessive sweat at least once a week, 80% are interested in a new technology to help them control their excessive sweat.11 Read More
- How many days a week do you feel bothered by your sweating?
- Do you need to change your clothes multiple times a day due to sweating?
- Do you select clothes based on how they may mask your sweating?
- How does your sweating make you feel in social or professional settings?
- What products or procedures have you tried to help control your sweating?
- Would you be interested in a modern approach to excessive sweat control based on the evolution of SweatTech through the decades?
Social and Emotional Impacts
2 Everts S. The Joy of Sweat: The Strange Science of Perspiration. 2021: W. W. Norton & Company, Inc.; New York, NY).
3 Lee K YC, Levell N J. Turning the tide: a history and review of hyperhidrosis treatment. JRSM Open. 2014 Jan; 5(1): 2042533313505511.
4 Doolittle, J., Walker, P., Mills, T. et al. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res 308, 743–749 (2016). https://doi.org/10.1007/s00403-016-1697-9.
5 McConaghy JR, Fosselman D. Hyperhidrosis: Management Options. Am Fam Physician. 2018 Jun 1;97(11):729-734.
6 Doolittle, J., Walker, P., Mills, T. et al. Hyperhidrosis: an update on prevalence and severity in the United States. Arch Dermatol Res 308, 743–749 (2016). https://doi.org/10.1007/s00403-016-1697-9.
7 American Academy of Dermatology. Hyperhidrosis: Who Gets and Causes. Available at https://www.aad.org/public/diseases/a-z/hyperhidrosis-causes. Accessed September 20, 2022.
8 International Hyperhidrosis Society. IHHS sweat survey reveals many are suffering in silence. Sweat Solutions. September-October 2008: 1-4.
9 Candesant Healthcare Provider Market Research – 2022.
10 Arora G, Kassir M, Patil A, et al. Treatment of Axillary hyperhidrosis. Journal of Cosmetic Dermatology. 2022 Jan;21(1):62-70. https://doi.org/10.1111/jocd.14378
11 Candesant Consumer Market Research – 2022.
12 McConaghy JR, Fosselman D. Hyperhidrosis: Management Options. Am Fam Physician. 2018 Jun 1;97(11):729-734.
13 Everts S. The Joy of Sweat: The Strange Science of Perspiration. 2021: W. W. Norton & Company, Inc.; New York, NY).